Washington University in St Louis · BiologyEgawa Immunology Lab
Takeshi Egawa · Saint Louis, Missouri
Research Focus
Dr. Takeshi Egawa's lab at Washington University focuses on understanding how CD8 T cells, a vital part of the immune system, make decisions about their fate when they respond to infections or vaccinations. By investigating the roles of specific signaling pathways and transcription factors, the lab aims to uncover the mechanisms that lead to T cell differentiation, memory formation, and their potential for use in immunotherapy against cancers. This research is essential for developing improved treatments that harness the body's immune response to fight chronic infections and cancer.
CD8 T cellscytokine signalingT cell differentiationtranscription factorsimmunotherapymemory T cellsgene regulationc-MYCimmune responseepigenetics
Research Aims
5AIM 01Investigate how TCR and cytokine receptor signaling influences CD8 T cell fate decisions.
AIM 02Dissect the gene regulatory networks involved in T cell differentiation and memory formation.
AIM 03Examine the role of the transcription factor c-MYC in lymphocyte proliferation and differentiation.
AIM 04Identify strategies to enhance memory lymphocyte generation for improved immune responses.
AIM 05Explore the potential of modifying differentiation pathways for therapeutic applications in immunotherapy.
Skills the Lab Values
PCRflow cytometrycell culturemouse modelsWestern blotRNA sequencingCRISPR/Cas technologyATAC-seqgene editingimmunological assays
Output against the department
Publications97bottom 34% of dept.681st of 1,033
this lab
most publishedleast published
Citations10ktop 36% of dept.367th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.