University of Chicago · GeneticsThe Actin Dynamics Lab
David R Kovar · Chicago, Illinois
Research Focus
Dr. David Kovar's research lab at the University of Chicago focuses on studying the actin cytoskeleton, which is crucial for cell shape, movement, and division. By examining how cells organize various actin networks using a limited supply of actin proteins, the lab seeks to uncover the complex interactions that dictate the structure and function of these networks. The research employs model organisms like fission yeast and C. elegans to explore the molecular mechanisms governing self-organization of actin filaments important for cellular processes.
actin cytoskeletonself-organizationactin-binding proteinsC. elegansfission yeastcell motilitycytokinesismolecular mechanismsactin networksprotein interaction
Research Aims
5AIM 01Investigate how cells allocate actin monomers between competing F-actin networks.
AIM 02Determine the roles of actin-binding proteins in regulating actin network size and density.
AIM 03Elucidate the mechanisms of ABP self-sorting to specific F-actin networks.
AIM 04Examine the competition and cooperation between actin-binding proteins for filament association.
AIM 05Study the intrinsic molecular mechanisms that define F-actin network characteristics.
Skills the Lab Values
cell culturemicroscopymolecular cloningprotein purificationWestern blotRNA sequencinggenetic manipulationbioinformaticsbiochemical assayslive-cell imaging
Output against the department
Publications140bottom 45% of dept.142nd of 259
this lab
most publishedleast published
Citations8.3kbottom 44% of dept.145th of 259
this lab
most citedleast cited
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