UMCUniversity of Massachusetts Chan Medical School · Microbiology & Immunology
Munro Lab
James B Munro · Worcester, Massachusetts
Research Focus
Dr. James Munro's lab conducts research focused on understanding viral mechanisms, particularly for HIV, influenza, and Ebola viruses. The lab investigates viral proteins that play critical roles in how viruses enter host cells and how they can potentially be targeted for better therapeutics. By exploring the structure and dynamics of viral membrane proteins, the lab aims to develop new strategies to treat or even eradicate viral infections.
HIVinfluenzaEbolaviral fusionantibody-dependent cellular cytotoxicity (ADCC)glycoproteinsmembrane dynamicsviral proteasetherapeutic developmentbiophysical studies
Research Aims
4AIM 01Identify structural features of HIV Env that enhance antibody-dependent cellular cytotoxicity.
AIM 02Understand the mechanisms of influenza hemagglutinin-mediated membrane fusion.
AIM 03Elucidate the dynamics of filovirus envelope glycoprotein during cell entry.
AIM 04Investigate the maturation processes of HIV-1 capsid and its implications for viral infectivity.
Skills the Lab Values
biophysical characterizationmolecular dynamics simulationssingle-molecule FRETcryoelectron tomographyantigen-antibody binding assayscell culture techniquesimmunofluorescenceprotein purificationstructural biology methodsviral infection models
Output against the department
Publications72bottom 22% of dept.376th of 486
this lab
most publishedleast published
Citations7.1ktop 50% of dept.241st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.