University of Florida · PharmacologyHypertension Research Lab
Steven Michael Smith · Gainesville, Florida
Research Focus
Dr. Steven Michael Smith's research lab at the University of Florida focuses on understanding the mechanisms behind hypertension, particularly resistant hypertension that does not respond to traditional treatments. The lab is investigating the role of gut microbiota and inflammation in blood pressure regulation, as well as how new technologies such as telehealth can improve hypertension management. They aim to discover novel ways to improve blood pressure control in patients through a combined approach of clinical trials and health technology analysis.
hypertensiongut microbiotaneuroinflammationminocyclinetelehealthblood pressure controlchronic kidney diseaseinflammatory responsehealth technology assessmentclinical trials
Research Aims
4AIM 01Investigate how minocycline alters gut microbiota to lower blood pressure in resistant hypertension.
AIM 02Assess the impact of minocycline on gut inflammation and gut leakiness and their relationship with blood pressure changes.
AIM 03Evaluate minocycline's effects on neuroinflammation in resistant hypertension.
AIM 04Examine how the effects of minocycline vary between White and African American individuals.
Skills the Lab Values
cell cultureanimal modelsflow cytometryPCRbiochemical assaysdata analysis using EHRclinical trial proceduresmixed methods researchstatistical analysismicrobiome analysis
Output against the department
Publications229top 36% of dept.165th of 462
this lab
most publishedleast published
Citations3.5kbottom 26% of dept.340th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.