University of California-Irvine · BiochemistryPeritoneal Carcinomatosis Research Lab
Christopher C. W. Hughes · Irvine, California
Research Focus
Dr. Christopher C. W. Hughes leads a research lab that focuses on developing advanced models for studying a form of cancer known as peritoneal carcinomatosis, particularly as it relates to colorectal and gastric cancers. The lab aims to create a microfluidic system that closely mimics human tissues to better understand tumor behavior and discover new treatments. Ultimately, their efforts will contribute to improved therapies for patients suffering from these aggressive cancers, addressing significant health disparities related to treatment outcomes.
peritoneal carcinomatosismicrophysiological systemsdrug repurposingcancer modelingtumor-on-a-chipcolorectal cancergastric cancerdrug sensitivitymicrofluidics
Research Aims
3AIM 01Characterize a dual-tissue platform that models peritoneal carcinomatosis.
AIM 02Correlate platform performance to in vivo data in a prospective clinical study.
AIM 03Test drug sensitivities of peritoneal carcinomatosis tumors using the VMT/VMP.
Skills the Lab Values
microfluidics3D cell culturedrug sensitivity testingin vitro modelingimmunohistochemistrycell proliferation assaysanimal models of cancerdata analysis with Pythonbiomimetic tissue engineering
Output against the department
Publications213top 37% of dept.149th of 402
this lab
most publishedleast published
Citations19ktop 23% of dept.92nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.