MCWMedical College of Wisconsin · Biochemistry
GPCR Signaling Research Lab
Adriano Marchese · Milwaukee, Wisconsin
Research Focus
Dr. Adriano Marchese's lab focuses on understanding how GPCR signaling works, particularly looking at a receptor involved in various diseases, including cancer. They aim to uncover the mechanisms behind this signaling to help develop new therapeutic strategies. The lab uses a variety of advanced techniques to study these complex interactions in cell models.
GPCR signalingchemokine receptorscell signalingdisease mechanismscancer researchdrug discovery
Research Aims
5AIM 01Investigate the structural determinants driving GPCR signaling.
AIM 02Explore the roles of A-kinase anchoring proteins in GPCR signaling.
AIM 03Understand how beta-arrestin interacts with non-GPCR binding partners.
AIM 04Define new concepts that may apply across the GPCR family.
AIM 05Provide insights to guide drug discovery efforts targeting GPCR signaling.
Skills the Lab Values
cell cultureconfocal microscopylive cell imagingbiochemical assaysfluorescence techniquesbiophysical modelingreconstitution assays
Output against the department
Publications107bottom 27% of dept.293rd of 402
this lab
most publishedleast published
Citations5.9kbottom 34% of dept.267th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.