Johns Hopkins University · PhysiologyGene Regulation and DNA Repair Lab
Yuan He · Baltimore, Maryland
Research Focus
Yuan He's lab at Johns Hopkins University studies how cells control gene expression and repair DNA damage. By investigating the processes involved in reading the genome and fixing broken DNA, the lab aims to understand how these actions prevent diseases like cancer. They use advanced imaging and molecular techniques to explore the complex interactions between proteins and DNA that keep our genetic information stable and functioning correctly.
gene expressionDNA damageDNA repairnon-homologous end joiningtranscription regulationgenome stabilitychromatin remodelingmolecular techniquescryoelectron microscopy
Research Aims
5AIM 01Investigate how cells initiate transcription to convert DNA into RNA.
AIM 02Examine the role of proteins in modifying chromatin to facilitate gene accessibility.
AIM 03Study the non-homologous end joining pathway for DNA repair.
AIM 04Analyze how improper DNA repair can lead to genomic instability.
AIM 05Explore the implications of transcription regulation for developing new therapies.
Skills the Lab Values
cryoelectron microscopyDNA repair analysisgene expression assayschromatin remodeling techniquesprotein interaction studiesmolecular cloningcell cultureWestern blotRNA extraction
Output against the department
Publications152top 49% of dept.141st of 286
this lab
most publishedleast published
Citations2.9kbottom 22% of dept.223rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.