University of Utah · BiochemistryThe Polycystic Protein Lab
Erhu Cao · Salt Lake City, Utah
Research Focus
Dr. Erhu Cao's lab focuses on understanding the structures and functions of proteins related to polycystic kidney disease and cation-chloride cotransporters, which play important roles in kidney function and brain activity. By studying these proteins, the lab aims to uncover mechanisms behind genetic disorders and explore new ways to treat conditions like hypertension, edema, and congenital heart defects. The research combines biochemical and structural analysis to inform the development of targeted therapies.
polycystic kidney diseasecation-chloride cotransporterskidney functionbrain disordersdrug development
Research Aims
5AIM 01Investigate the structures and functions of polycystin protein complexes involved in kidney disease.
AIM 02Examine the role of cation-chloride cotransporters in renal salt handling and neuronal signaling.
AIM 03Identify how therapeutics interact with target proteins and elucidate their regulatory mechanisms.
AIM 04Develop assays for high-throughput screening of drug candidates that modulate cotransporter activities.
AIM 05Clarify the molecular underpinnings of genetic mutations leading to diseases like congenital heart defects.
Skills the Lab Values
cryoelectron microscopyprotein purificationcell culturebiochemical assaysmolecular cloningstructural biology methodsion flux assayspharmacological screeningdata analysis using Python
Output against the department
Publications152bottom 43% of dept.230th of 402
this lab
most publishedleast published
Citations6.1kbottom 35% of dept.263rd of 402
this lab
most citedleast cited
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