WMCWeill Medical College of Cornell University · Physiology
Laughney Cancer Lab
Ashley Marie Laughney · New York, New York
Research Focus
The lab led by Dr. Ashley Marie Laughney investigates how certain proteins influence cancer development and progression, particularly focusing on the STING protein and chromosomal instability in tumor cells. By developing a new technology called SatSeq, the research aims to map how changes in these proteins affect cancer behavior and responses to therapy. The lab also strives to understand the interactions between cancer cells and their surrounding environment, which can impact the progression and spread of different cancer types.
STINGchromosomal instabilitycancer progressiontumor microenvironmentmonoclonal antibodiesimmunotherapydrug resistance
Research Aims
4AIM 01Develop SatSeq technology to explore STING functionality in cancer.
AIM 02Investigate the impact of chromosomal instability on cancer cell behavior.
AIM 03Assess how cancer cells interact with the tumor microenvironment.
AIM 04Determine if ER-stress responses can be targeted therapeutically.
Skills the Lab Values
saturation mutagenesissingle-cell sequencingDNA barcodingmouse modelsRNA sequencingflow cytometrycell culturebiochemical assayscomputational analysis
Output against the department
Publications99bottom 28% of dept.206th of 286
this lab
most publishedleast published
Citations4.9kbottom 42% of dept.167th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.