Drexel University · EngineeringCartilage Mechanobiology Lab
Lin Han · Philadelphia, Pennsylvania
Research Focus
Dr. Lin Han's lab focuses on understanding the role of type III collagen in cartilage health, especially how it affects cartilage structure and mechanics. They study how changes in collagen levels influence cartilage development and diseases like osteoarthritis. The lab employs innovative techniques, including special mouse models and advanced imaging methods, to explore how collagen III can be utilized for improving treatments for joint disorders and enhancing tissue engineering.
type III collagencartilageosteoarthritismechanobiologymatrix assembly
Research Aims
3AIM 01Investigate the role of collagen III in cartilage matrix assembly.
AIM 02Examine how loss of collagen III accelerates cartilage degeneration in osteoarthritis.
AIM 03Determine the effects of collagen III on chondrocytes under mechanical loading.
Skills the Lab Values
3D hydrogel cultureatomic force microscopyimmunofluorescence imaginggene expression analysismouse modelsbiomechanical testingcollagen matrix studiesmechanotransduction pathways
Output against the department
Publications462top 13% of dept.36th of 278
this lab
most publishedleast published
Citations27ktop 13% of dept.35th of 278
this lab
most citedleast cited
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