Case Western Reserve University · BiologyGlycoprotein Dynamics and Therapeutics Lab
Brian A Cobb · Cleveland, Ohio
Research Focus
Dr. Brian A. Cobb's lab at Case Western Reserve University studies the complex world of glycoproteins, especially how their sugar structures influence immune responses. The team's research focuses on how glycosylation (the addition of sugar molecules to proteins), particularly on antibodies, can be modulated for therapeutic benefits in diseases like autoimmunity and inflammation. By understanding the mechanisms behind these modifications, the lab aims to create new treatments that can better manage inflammatory diseases through targeted therapies.
glycoproteinsglycosylationsialylationautoimmune diseasesinflammationantibody modulationvascular biologytherapeuticsglycobiologyendothelial cells
Research Aims
3AIM 01Define the biochemical mechanisms of IgG sialylation in endothelial cells.
AIM 02Investigate the changes in IgG sialylation during inflammatory responses.
AIM 03Develop therapies that can modulate the glycosylation of antibodies for disease treatment.
Skills the Lab Values
cell cultureconfocal microscopybiochemical assaysprotein purificationflow cytometrymolecular biology techniquesWestern blottingin vitro analysisdata analysis in immunologyanimal models
Output against the department
Publications318top 17% of dept.175th of 1,033
this lab
most publishedleast published
Citations4.5kbottom 35% of dept.674th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.