WMCWeill Medical College of Cornell University · Microbiology & Immunology
Antibiotic Discovery Lab
Ruslana Bryk · New York, New York
Research Focus
Dr. Ruslana Bryk's lab focuses on developing new antibiotics to combat tuberculosis (TB) and non-tuberculous mycobacterial (NTM) diseases. They study a specific target in bacteria, lipoamide dehydrogenase (Lpd), to discover and optimize new drug candidates that can effectively kill these pathogens. The lab aims to understand the mechanisms of these inhibitors, improving their effectiveness and addressing the rise of drug-resistant strains.
tuberculosisantibioticslipoamide dehydrogenasenon-tuberculous mycobacteriadrug resistance
Research Aims
5AIM 01Explore tight binding inhibitors of lipoamide dehydrogenase in Mtb.
AIM 02Define features that contribute to antibacterial activity of Lpd inhibitors.
AIM 03Develop a framework to enhance the efficacy of new antibiotics against TB and NTM.
AIM 04Characterize structural features of mycobacterial enzymes to understand their functionality.
AIM 05Test new inhibitors on various mycobacterial species to assess their effectiveness in culture and during infection.
Skills the Lab Values
enzyme kineticsbinding assaysstructure-guided designmolecular biologycell culture
Output against the department
Publications32bottom 6% of dept.458th of 486
this lab
most publishedleast published
Citations2.7kbottom 17% of dept.403rd of 486
this lab
most citedleast cited
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