EUEmory University · Biomedical Engineering
Breast Cancer Immunotherapy Lab
David Sung-Wen Yu · Atlanta, Georgia
Research Focus
Dr. David Sung-Wen Yu's lab focuses on understanding how a protein called SAMHD1 affects the response of breast cancer cells to radiation therapy and immunotherapy. The research aims to uncover the mechanisms by which SAMHD1 influences the immune environment in triple-negative breast cancer and explore novel strategies to improve treatment outcomes by targeting this protein. By doing so, the lab hopes to identify potential biomarkers for patient selection and develop innovative ways to enhance cancer therapy effectiveness.
breast cancerimmunotherapyradiation therapySAMHD1triple-negative breast cancerimmune checkpointCD8+ T cellstumor microenvironment
Research Aims
3AIM 01Determine how SAMHD1 influences radiation and immune responses in breast cancer.
AIM 02Investigate SAMHD1's role in the immune dynamics of triple-negative breast cancer patients.
AIM 03Assess if degrading SAMHD1 with VLPs enhances breast cancer sensitivity to radiation and immunotherapy.
Skills the Lab Values
cell culturein vivo mouse modelsflow cytometryWestern blotDNA damage assessmentPCRvirus-like particle manipulationimmunohistochemistry
Output against the department
Publications210bottom 49% of dept.305th of 595
this lab
most publishedleast published
Citations5.6kbottom 43% of dept.338th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.