University of Michigan-Ann Arbor · BiologyThe Neutrophil Nexus
Jennifer C Brazil · Ann Arbor, Michigan
Research Focus
Dr. Jennifer C. Brazil's lab at the University of Michigan focuses on understanding how neutrophils, a type of white blood cell, behave during intestinal inflammation, particularly in diseases like inflammatory bowel disease (IBD). The lab studies the role of a protein called CD45 in regulating the function and activation of neutrophils, with the aim of developing new therapies to reduce harmful inflammation in the gut. This research has the potential to improve treatment options and enhance the quality of life for patients suffering from IBD.
neutrophilsinflammatory bowel diseaseintestinal inflammationCD45immune regulation
Research Aims
5AIM 01Investigate how CD45 regulates neutrophil migration during intestinal inflammation.
AIM 02Examine the effects of neutrophil-specific CD45 deficiency on IBD pathology.
AIM 03Identify specific CD45 isoforms that can be targeted to modulate neutrophil activation.
AIM 04Determine the intracellular signaling pathways affected by CD45 activity in neutrophils.
AIM 05Explore potential therapeutic strategies to reduce inflammation in IBD by targeting CD45.
Skills the Lab Values
mouse modelscell cultureflow cytometryWestern blotimmunohistochemistryantibody productionsignal transduction analysisin vivo imagingprotein purification
Output against the department
Publications93bottom 31% of dept.705th of 1,033
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.849th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.