Li Lab
Hongmin Li · Tucson, Arizona
University of Arizona · Pharmacology
Research focus
Dr. Hongmin Li's lab focuses on developing new antiviral drugs specifically targeting flaviviruses, which are viruses transmitted by insects like mosquitoes and are known to cause serious illnesses in humans. The lab investigates essential viral enzymes to find compounds that can inhibit the viruses' ability to replicate and evade the immune system. Through advanced techniques in medicinal chemistry and biochemistry, the lab aims to create effective treatments for infections such as dengue and Japanese encephalitis.
flavivirusantiviral drug developmentmethyltransferase inhibitorsbiochemical assayshigh-throughput screening
Research aims
5AIM 01Optimize existing lead compounds for flavivirus inhibitors.
AIM 02Conduct high-throughput screening to identify new antiviral candidates.
AIM 03Investigate the mechanism of action of antiviral compounds.
AIM 04Assess the pharmacokinetics of lead candidates in vivo.
AIM 05Develop first-in-class therapeutic agents against flavivirus infections.
Skills the lab values
medicinal chemistryhigh-throughput screening (HTS)in vitro biochemistrystructural biologyanimal models of disease
Output against the department
392publicationstop 16% of the department75th of 462
most publishedleast published
12kcitationstop 33% of the department151st of 462
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.