EUEmory University · Biology
The Gut Immunity Lab
Souheil Antoine Younes · Atlanta, Georgia
Research Focus
Dr. Souheil Younes's research lab at Emory University focuses on understanding how the gut microbiome affects CD4 T cells in HIV-1 infected individuals who do not respond to treatment. The lab investigates the role of specific bacterial toxins produced in the gut that may hinder the recovery of CD4 T cells and contribute to health complications in these patients. By exploring the connections between bacteria, toxins, and immune response, the lab aims to identify new therapeutic targets to improve health outcomes for these individuals.
HIV-1CD4 T cellsgut microbiomebacterial toxinsimmune responseinflammationmitochondrial dysfunctiondysbiosisapoptosis
Research Aims
3AIM 01Investigate the correlation between gut-derived toxins and CD4 T cell counts in HIV-1 infected individuals.
AIM 02Explore the mechanisms by which bacterial toxins induce mitochondrial dysfunction in T cells.
AIM 03Analyze the gut microbiome composition in immune non-responders to identify dysbiotic features.
Skills the Lab Values
flow cytometryelectron microscopycell culturePCRmetagenomicsmetaproteomicsmass spectrometryapoptosis assaysbiochemical assays
Output against the department
Publications8bottom 1% of dept.1,022nd of 1,033
this lab
most publishedleast published
Citations928bottom 4% of dept.990th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.