Yale University · NeuroscienceMeningeal Lymphatics and Neuroimmunity Lab
Jean-Leon Thomas · New Haven, Connecticut
Research Focus
The lab led by Dr. Jean-Leon Thomas at Yale University focuses on understanding how specialized blood vessels in the brain called meningeal lymphatic vessels influence the immune system during early development. The research emphasizes the relationship between these vessels and neuroimmune communication, particularly in relation to pediatric brain tumors like medulloblastoma. By utilizing advanced imaging techniques and genetic mouse models, the lab aims to uncover how these vessels can enhance T cell education and potentially improve treatments for childhood cancers.
meningeal lymphaticsneuroimmune communicationT cell educationmedulloblastomapediatric brain tumorsVEGF-Clight sheet microscopysingle cell RNA sequencingimmune response
Research Aims
5AIM 01Investigate how developing meningeal lymphatic vessels impact neuroimmune communication.
AIM 02Characterize antigen-presenting cell transport to lymph nodes.
AIM 03Examine the role of VEGF-C in meningeal lymphatic vessel growth.
AIM 04Identify key regulators of lymphatic vessel development like Nrp2.
AIM 05Explore the potential of enhancing T cell education in relation to pediatric brain tumors.
Skills the Lab Values
3D fluorescence microscopymouse genetic modelslymphatic vessel imagingflow cytometryliquid chromatographymass spectrometryRNA sequencingimmunological assaysT cell characterization
Output against the department
Publications143bottom 49% of dept.338th of 671
this lab
most publishedleast published
Citations9.6ktop 42% of dept.279th of 671
this lab
most citedleast cited
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