Augusta University · NeuroscienceEntorhinal Cortex Research Group
Yun Lei · Augusta, Georgia
Research Focus
Dr. Yun Lei's lab at Augusta University focuses on understanding how specific neurons in the brain, particularly in the entorhinal cortex, are affected by Alzheimer's disease (AD) as we age. The research investigates the role of epigenetic changes, particularly involving a protein called EZH2, in the loss of these neurons and cognitive decline associated with AD. By exploring these mechanisms, the lab aims to uncover potential therapeutic targets for preventing or mitigating AD-related neuronal damage.
Alzheimer's Diseaseepigeneticsneuronal vulnerabilitycognitive impairmententorhinal cortex
Research Aims
3AIM 01Investigate the role of EZH2 in entorhinal PV neurons during aging and Alzheimer's disease.
AIM 02Examine how EZH2 protects against amyloid and tau pathology in mouse models of Alzheimer's disease.
AIM 03Identify molecular pathways affected by EZH2 that lead to neuronal dysfunction and degeneration.
Skills the Lab Values
molecular biology techniquesmouse modelsgene expression analysishistone methylation studiescell culture
Output against the department
Publications181top 42% of dept.279th of 671
this lab
most publishedleast published
Citations4.4kbottom 32% of dept.453rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.