Columbia University in the City of New York · NeuroscienceCerebellar Disorders Research Group
Sheng-Han Kuo · New York, New York
Research Focus
Dr. Sheng-Han Kuo's lab at Columbia University focuses on understanding and developing therapies for cerebellar disorders such as ataxia and essential tremor. The lab investigates how specific changes in brain cell function and structure contribute to these disorders, aiming to restore normal brain circuit activity. By utilizing mouse models and human brain samples, the research seeks to uncover new treatment options for patients who currently have limited therapies available.
cerebellar degenerationessential tremorPurkinje cellscalcium handlingataxianeurodegenerationsynaptic therapiesmouse modelsdisease mechanisms
Research Aims
3AIM 01Investigate the effects of CF-PC synaptic intervention on ataxia symptoms in cerebellar degeneration.
AIM 02Determine how structural changes in Purkinje cells contribute to essential tremor progression.
AIM 03Develop therapies targeting abnormal calcium handling in Purkinje cells to alleviate tremor symptoms.
Skills the Lab Values
mouse modelssynaptic intervention techniquestremor assessmentcalcium imagingbehavioral assayspostmortem brain analysisimmunohistochemistryelectrophysiologydata analysis with Python
Output against the department
Publications264top 27% of dept.182nd of 671
this lab
most publishedleast published
Citations15ktop 27% of dept.182nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.