Pennsylvania State University-Main Campus · PhysiologyMitochondrial Calcium and Cancer Lab
Shengyu Yang · University Park, Pennsylvania
Research Focus
Dr. Shengyu Yang's lab at Pennsylvania State University focuses on understanding how mitochondrial calcium signals affect the spread and advancement of pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). They explore the molecular mechanisms behind cell migration and invasion in cancer, aiming to identify potential therapeutic targets to better treat this aggressive cancer. The research may lead to innovative approaches that could help prevent the recurrence of metastatic pancreatic cancer.
pancreatic cancermitochondrial calcium signalingmetastasisNrf2 signalingcystine uptake
Research Aims
3AIM 01Investigate the role of MCU-Nrf2 signaling in PDAC metastasis
AIM 02Determine the mechanism by which MCU activates Nrf2
AIM 03Define cystine addiction as a therapeutic vulnerability in MCU overexpressing PDAC
Skills the Lab Values
genetically engineered mouse modelsRNA sequencingcell cultureflow cytometryWestern blot
Output against the department
Publications95bottom 26% of dept.211th of 286
this lab
most publishedleast published
Citations3.8kbottom 31% of dept.198th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.