University of Washington-Seattle Campus · Biomedical EngineeringRegnier Lab
Michael Regnier · Seattle, Washington
Research Focus
Dr. Michael Regnier's lab at the University of Washington focuses on studying myosin, a key protein in muscle contraction, to understand how genetic mutations affect heart health. By using advanced computer simulations and experimental models, the lab examines the structural and functional impact of specific protein variants associated with heart diseases. Their work combines cutting-edge techniques like molecular dynamics and high-resolution imaging, aiming to enhance understanding of cardiac conditions at the cellular level.
myosincardiac myocytesgenetic mutationsstructure-function relationshipexperimental modelscomputational modelingstem cells
Research Aims
5AIM 01Develop computational models to predict how myosin variants affect muscle function.
AIM 02Use gene edited human stem cells to validate simulation outcomes.
AIM 03Investigate the structural changes in myosin using super-resolution imaging.
AIM 04Examine the effects of myosin mutations on contractile properties of muscle cells.
AIM 05Apply a platform to assess variants of unknown significance in cardiac diseases.
Skills the Lab Values
molecular dynamics simulationsgene editingcryo-electron microscopysingle molecule imagingbiochemical assayscell culture of cardiac myocytescomputational modelinghigh-resolution imaging techniques
Output against the department
Publications385top 23% of dept.135th of 595
this lab
most publishedleast published
Citations12ktop 30% of dept.178th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.