Boston University · Biomedical EngineeringAlzheimer's Disease and Environmental Toxicants Lab
Lee E. Goldstein · Boston, Massachusetts
Research Focus
Dr. Lee E. Goldstein's research lab at Boston University focuses on understanding Alzheimer's disease (AD) and related dementias by investigating how environmental toxicants like lead, cadmium, and arsenic affect brain aging and disease risk. The lab employs innovative mouse models to delve into the molecular processes that connect genetic risk factors and environmental exposures. Additionally, they are developing a novel noninvasive eye scanner to detect early biomarkers of Alzheimer’s in the lens of the eye, aiming for a more accessible method of early detection of cognitive decline.
Alzheimer's diseasebiomarkersenvironmental toxicantsmouse modelsneuroinflammationaginggeneticscognitionearly detectionmetallomics
Research Aims
5AIM 01Investigate the effects of toxic metal exposures on brain aging and Alzheimer's disease using advanced mouse models.
AIM 02Validate lens beta-amyloid as a novel and noninvasive biomarker for early detection of Alzheimer's disease.
AIM 03Explore the genetic and environmental interactions that influence Alzheimer's disease risk.
AIM 04Develop a new eye scanner for detecting amyloid beta in the lens as an alternative to traditional methods.
AIM 05Assess the impact of neurotoxicants on cognitive function and neuroinflammatory processes in preclinical models.
Skills the Lab Values
cell culturemouse modelslongitudinal studiesimmunohistochemistrybehavioral testingmultimodal imagingmolecular biology techniquesdata integrationbioinformaticsepigenomics
Output against the department
Publications238top 43% of dept.256th of 595
this lab
most publishedleast published
Citations17ktop 22% of dept.133rd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.