University of California-San Diego · BiologyPlacental Biology and Regenerative Medicine Lab
Mana M Parast · La Jolla, California
Research Focus
Dr. Mana M Parast's lab focuses on understanding the complex biology of the human placenta, particularly how its structure and function relate to pregnancy outcomes such as preeclampsia and fetal growth restriction. They utilize advanced techniques in single-cell analysis and tissue modeling to explore the properties of placental cells and their interactions, aiming to enhance our understanding of placental dysfunction and develop potential regenerative strategies. This research is crucial as it reveals insights into conditions like Trisomy 21, which significantly affects placental health and fetal development.
placental dysfunctionpreeclampsiaTrisomy 21trophoblastsingle-cell RNA sequencingstem cellsextracellular matrixtissue modelingdigital spatial profilingplacental development
Research Aims
5AIM 01Characterize the structural and functional relationships within the human placenta.
AIM 02Investigate trophoblast progenitor heterogeneity in normal and Trisomy 21-affected placentae.
AIM 03Implement novel technologies to map molecular changes associated with placental dysfunction.
AIM 04Model placental dysfunction using in vitro cultures derived from primary cells.
AIM 05Assess cellular responses to extracellular matrix signals in trophoblast differentiation.
Skills the Lab Values
single-cell RNA sequencingtissue culturedigital spatial profilingmass spectrometrybiological modelingcell differentiation assayspluripotent stem cell manipulationimmunostaininghistopathology analysisextracellular matrix studies
Output against the department
Publications2,950top 1% of dept.1st of 1,033
this lab
most publishedleast published
Citations7.5ktop 49% of dept.507th of 1,033
this lab
most citedleast cited
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