George Washington University · NeuroscienceChamberlain Lab
Jeffrey S Chamberlain · Washington, District of Columbia
Research Focus
Dr. Jeffrey Chamberlain's lab focuses on developing advanced gene therapies for Duchenne muscular dystrophy (DMD), a severe genetic disorder. The lab aims to improve the delivery and function of dystrophin proteins, utilizing innovative vector technologies. By designing new methods for gene replacement and editing, the research seeks to enhance the effectiveness and safety of treatments for DMD and related neuromuscular disorders.
Duchenne muscular dystrophygene therapydystrophinAAV vectorsgene editingantibody therapymyotropic AAV capsidsmuscle satellite cells
Research Aims
3AIM 01Develop advanced gene replacement methods for dystrophin using improved vector systems.
AIM 02Refine gene editing techniques to enhance dystrophin expression in muscle cells.
AIM 03Evaluate the therapeutic effects of new dystrophin delivery methods in response to injury.
Skills the Lab Values
AAV vector designgene editingCRISPRPCRcell cultureprotein purificationanimal modelsWestern blotRNA sequencingmicroscopy
Output against the department
Publications357top 18% of dept.121st of 671
this lab
most publishedleast published
Citations25ktop 16% of dept.106th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.