Tufts University · ChemistryChemical Modifications and Cellular Signaling Lab
Rebecca Scheck · Medford, Massachusetts
Research Focus
The Scheck lab at Tufts University focuses on understanding how chemical modifications of proteins, specifically glycation and ubiquitination, impact cellular functions and contribute to diseases like cancer and diabetes. By developing innovative tools to study these modifications in living cells, the lab aims to uncover new therapeutic targets for addressing age-related disorders and other health issues. Their research combines advanced chemical biology techniques with a deep understanding of cellular signaling networks.
glycationubiquitinationchemical biologycellular signalingtherapeutic targetsproteomicsage-related disordersdisease mechanismsprotein modifications
Research Aims
5AIM 01Develop novel chemical biology tools to study glycation and ubiquitination in living cells.
AIM 02Investigate the interplay between glycation and ubiquitination in cellular signaling.
AIM 03Uncover new links between post-translational modifications and disease processes.
AIM 04Optimize technologies for profiling ubiquitin pathways in human cells.
AIM 05Explore how glycation influences chromatin remodeling and gene expression.
Skills the Lab Values
protein purificationmass spectrometrycell culture techniquesquantitative proteomicsfluorescence microscopygenetic engineeringhistone modification analysisbioinformaticsin vitro transcription assays
Output against the department
Publications42bottom 8% of dept.199th of 216
this lab
most publishedleast published
Citations1.4kbottom 11% of dept.193rd of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.