UMCUniversity of Massachusetts Chan Medical School · Biology
Davis Metabolism Lab
Roger J. Davis · Worcester, Massachusetts
Research Focus
Dr. Roger J. Davis's lab at the University of Massachusetts Medical School focuses on understanding how obesity impacts metabolic health. The research specifically investigates the role of JNK signaling pathways in fat tissue, aiming to uncover how these pathways contribute to inflammation and insulin resistance associated with obesity. By identifying molecular mechanisms involved in these processes, the lab seeks to inform new treatment strategies for metabolic syndrome and type 2 diabetes.
obesitymetabolic syndromeinsulin resistanceJNK signalingadipose tissue
Research Aims
4AIM 01Investigate the role of JNK isoforms in adipose tissue inflammation.
AIM 02Determine the effects of JNK on adipokine expression in obesity.
AIM 03Assess the mechanisms by which JNK contributes to insulin resistance in adipocytes.
AIM 04Identify novel therapeutic targets related to JNK signaling in metabolic syndrome.
Skills the Lab Values
cell culturemolecular cloningWestern blotRNA extraction and analysisreal-time PCRanimal modelsadipocyte differentiationgene expression analysisbioinformatics
Output against the department
Publications808top 2% of dept.25th of 1,033
this lab
most publishedleast published
Citations112ktop 1% of dept.11th of 1,033
this lab
most citedleast cited
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