Johns Hopkins University · BiologyCervical Cancer Immunotherapy Unit
Tzyy-Choou Wu · Baltimore, Maryland
Research Focus
Dr. Tzyy-Choou Wu's lab focuses on developing effective cancer vaccines specifically for cervical cancer caused by human papillomavirus (HPV). They are investigating how different genetic variants of HPV can evade the immune system and impact cancer growth. The lab aims to create a therapeutic vaccine that works for diverse populations, addressing disparities in cervical cancer outcomes around the world.
HPVcervical cancerimmunotherapycancer vaccinesimmune evasiontumor microenvironmenttransgenic miceDNA vaccines
Research Aims
3AIM 01Characterize immune evasion mechanisms of different HPV E6/E7 variants.
AIM 02Study the tumor microenvironment and growth rates in HPV-driven carcinomas in mice.
AIM 03Evaluate the efficacy of a novel DNA vaccine against spontaneous cervical carcinomas.
Skills the Lab Values
cell culturemouse modelsimmunoassaysantigen mappingPCRDNA sequencingflow cytometrytissue analysis
Output against the department
Publications23bottom 3% of dept.1,005th of 1,033
this lab
most publishedleast published
Citations1.3kbottom 8% of dept.952nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.