Wayne State University · GeneticsAdipose Biology and Metabolism Lab
James G Granneman · Detroit, Michigan
Research Focus
Dr. James G. Granneman's lab focuses on understanding how fat tissue is formed and maintained, and how it can change in response to various conditions. The research explores the interactions between different cell types in fat tissue and how these interactions can affect metabolic health. By using advanced techniques like CRISPR and spatial transcriptomics, the lab aims to shed light on how fat cells develop and function, which could lead to new treatments for obesity and diabetes.
adipose tissuecellular plasticitymetabolic healthCRISPRspatial transcriptomicsobesitydiabetescell interactionsadipogenesis
Research Aims
5AIM 01Investigate the mechanisms of adipose tissue formation and remodeling.
AIM 02Map the cellular interactions within adipogenic niches using spatial transcriptomics.
AIM 03Study the lineage relationships of different cell types in postnatal adipose tissue.
AIM 04Evaluate how these cellular dynamics relate to metabolic health and disease.
AIM 05Explore potential interventions for obesity-related metabolic conditions.
Skills the Lab Values
CRISPR/Cas9spatial transcriptomicssingle-cell RNA sequencingimmunofluorescencemultiplexed 3D fluorescence in situ hybridizationcell cultureflow cytometrymouse modelsproteomics
Output against the department
Publications202top 42% of dept.108th of 259
this lab
most publishedleast published
Citations12ktop 44% of dept.114th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.