University of California-San Francisco · BiologyLung Fibrosis and Inflammation Unit
Stephen L Nishimura · San Francisco, California
Research Focus
Dr. Stephen L. Nishimura's lab at UCSF focuses on understanding how the transforming growth factor-beta (TGF-β) cytokine regulates fibrosis and inflammation in the lungs. Their research aims to uncover the molecular mechanisms of TGF-β activation to develop more targeted and effective therapies for lung diseases like pulmonary fibrosis, which currently have few treatment options.
TGF-betalung fibrosisinflammationintegrinscryogenic electron microscopy
Research Aims
4AIM 01Investigate how structural changes in the TGF-β and integrin complex affect cytokine activation.
AIM 02Develop techniques for predicting and manipulating entropy changes in protein complexes.
AIM 03Assess the role of the cellular membrane environment on TGF-β activation.
AIM 04Explore the therapeutic potential of targeting the activation pathways of TGF-β.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)protein engineeringbiochemical assaysrecombinant antibody techniquesin vivo lung models
Output against the department
Publications127bottom 45% of dept.561st of 1,033
this lab
most publishedleast published
Citations8.5ktop 45% of dept.461st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.