Ohio State University-Main Campus · BiochemistryKuret Lab
Jeff Kuret · Columbus, Ohio
Research Focus
Dr. Jeff Kuret's lab at Ohio State University focuses on understanding tau aggregates, which play a crucial role in Alzheimer's disease and related conditions. The research explores how tau proteins misfold and form unique structures that contribute to neurodegeneration. By studying these aggregates, the lab aims to develop better diagnostic tools and therapies for tauopathies by clarifying the molecular mechanisms involved in tau aggregation and how they can be targeted by small molecules.
tau aggregationAlzheimer's diseaseneurodegenerationtauopathiesprion-like mechanismsbiochemical assaysstructural biologymolecular interactionsdiagnostic strategiestherapeutic interventions
Research Aims
4AIM 01Determine how tau phosphorylation affects the formation of tau aggregates.
AIM 02Clarify how common nucleation motifs in tau contribute to aggregation.
AIM 03Test if tau polymorphism propagates through prion-like mechanisms.
AIM 04Identify interactions that influence the binding of small molecules to tau aggregates.
Skills the Lab Values
biochemical assayscryoelectron microscopyprotein purificationcell cultureimaging techniquesligand binding studiesaggregation assaysmolecular modelingdata analysis in biochemistrystructural analysis
Output against the department
Publications128bottom 36% of dept.255th of 402
this lab
most publishedleast published
Citations14ktop 36% of dept.144th of 402
this lab
most citedleast cited
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