University of Alabama at Birmingham · NeuroscienceDay Epigenetics Lab
Jeremy J Day · Birmingham, Alabama
Research Focus
Dr. Jeremy J. Day's lab studies how substances like cocaine affect the brain, particularly in regions linked to reward and motivation. They focus on understanding the roles of specific proteins, Gadd45b and Reelin, in altering gene expression and behavior when exposed to drugs. By exploring these molecular mechanisms, the lab aims to uncover new therapeutic targets for addiction treatment and enhance our understanding of motivated behavior disorders.
cocaineepigeneticsGadd45bReelinbehavioral plasticitynucleus accumbensdrug addictiongene expressionsynaptic plasticity
Research Aims
4AIM 01Investigate the role of Gadd45b in cocaine-induced epigenetic changes in the brain.
AIM 02Examine how Gadd45b affects memory formation related to cocaine use.
AIM 03Determine the influence of Reelin on synaptic properties in response to cocaine.
AIM 04Explore how Reelin signaling alters behavioral responses to cocaine.
Skills the Lab Values
PCRCRISPRRNA sequencingsingle-cell RNA sequencingcell cultureelectrophysiologybehavioral assaysdata analysisin vivo manipulation
Output against the department
Publications157top 48% of dept.317th of 671
this lab
most publishedleast published
Citations6.9kbottom 47% of dept.355th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.