Columbia University in the City of New York · NeuroscienceMccallum Lab
James Mccallum Noble · New York, New York
Research Focus
Dr. James Mccallum Noble's lab is focused on understanding the links between oral health, specifically periodontal infections, and Alzheimer's Disease. They are investigating how periodontitis may contribute to cognitive impairment and dementia in older adults. By studying a diverse group of elderly participants over time, they aim to uncover potential mechanisms connecting these two health issues and provide insights for prevention and early intervention strategies.
Alzheimer's Diseaseperiodontitiscognitive impairmentdementiaoral healthbiomarkersneuroimaginginflammationlongitudinal studies
Research Aims
5AIM 01Examine the relationship between periodontal infections and cognitive impairment in older adults.
AIM 02Identify biomarkers associated with Alzheimer's Disease and periodontitis.
AIM 03Assess changes in oral health over time in a longitudinal cohort study.
AIM 04Investigate the inflammatory response linked to periodontitis and cognitive decline.
AIM 05Determine the public health implications of periodontitis as a modifiable risk factor for dementia.
Skills the Lab Values
clinical assessmentsmicrobiological techniques16S rRNA sequencingmetagenomic analysisMRI imagingneuropsychological testingdata collectionparticipant recruitmentstatistical analysis
Output against the department
Publications270top 26% of dept.177th of 671
this lab
most publishedleast published
Citations8.1ktop 46% of dept.311th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.