Washington University in St Louis · BiochemistryLi Vitamin K Lab
Weikai Li · Saint Louis, Missouri
Research Focus
Dr. Weikai Li's lab at Washington University is focused on understanding the vitamin K cycle, which is essential for blood clotting and maintaining healthy bones and blood vessels. Their research aims to uncover the structural and functional mechanisms behind the proteins involved in this cycle, particularly how they can be modulated to improve anticoagulation therapy and support cardiovascular health. This work has important implications for treating diseases related to blood coagulation and cardiovascular disorders.
vitamin K cycleanticoagulationblood coagulationferroptosisvascular healthcardiovascular diseasesstructural biologyprotein dynamics
Research Aims
3AIM 01Identify new anticoagulation strategies via VKOR redox states.
AIM 02Elucidate the interplay of the vitamin K cycle in carboxylation and ferroptosis.
AIM 03Understand the structural mechanisms of -carboxylation.
Skills the Lab Values
structural analysisX-ray crystallographycryoelectron microscopyprotein expressioncell culturebiochemical assaysredox biologymolecular dockingenzymatic assays
Output against the department
Publications76bottom 15% of dept.343rd of 402
this lab
most publishedleast published
Citations2.4kbottom 9% of dept.366th of 402
this lab
most citedleast cited
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