University of Michigan-Ann Arbor · BiochemistryJakob Lab
Ursula H. Jakob · Ann Arbor, Michigan
Research Focus
Dr. Ursula H. Jakob's lab at the University of Michigan focuses on understanding how cells maintain protein homeostasis, which is vital for preventing diseases such as Alzheimer's and Parkinson's. The lab studies two main areas: the role of inorganic polyphosphate in stress resistance and amyloid toxicity, and how epigenetic changes, specifically histone modifications, influence the aging process and healthspan. By exploring these mechanisms in model organisms, the lab aims to uncover new strategies for promoting longevity and combating neurodegenerative diseases.
protein homeostasispolyphosphateepigeneticsH3K4me3oxidative stressagingneurodegenerative diseasesamyloid toxicityC. elegansmammalian cells
Research Aims
5AIM 01Investigate how polyphosphate protects against protein aggregation and neurotoxicity.
AIM 02Understand the role of histone modifications in regulating protein homeostasis.
AIM 03Explore how early-life oxidative stress influences longevity and healthspan.
AIM 04Identify conserved mechanisms linking oxidative stress and epigenetic changes across species.
AIM 05Develop new therapeutics aimed at slowing aging and preventing neurodegenerative diseases.
Skills the Lab Values
cell culturebiochemical assayscryo-electron microscopygenetic manipulationhistone modification analysisprotein purificationmicroscopy techniquesdata analysis in biologymodel organism studiesstress response assessment
Output against the department
Publications183top 46% of dept.185th of 402
this lab
most publishedleast published
Citations16ktop 28% of dept.112th of 402
this lab
most citedleast cited
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