University of Hawaii at Manoa · BiologyWard Spermatogenesis Lab
Monika A Ward · Honolulu, Hawaii
Research Focus
Dr. Monika A Ward's lab at the University of Hawaii at Manoa focuses on understanding how certain genes on the Y chromosome, specifically Zfy1 and Zfy2, influence male reproduction in mice. By investigating these genes and their roles in spermatogenesis, the lab aims to uncover molecular mechanisms underlying male fertility, which could shed light on similar processes in humans and contribute to understanding male infertility.
Y chromosomespermatogenesismale reproductionZfy genesgenetic regulation
Research Aims
3AIM 01Identify the effects of Zfy gene loss on spermatogenic cell transcript and protein expression.
AIM 02Utilize CRISPR/Cas9 to create tagged mouse models of Zfy1 and Zfy2 for studying protein and chromatin interactions.
AIM 03Integrate findings from transcriptomic and proteomic analyses to map the regulatory network influenced by ZFY in the mouse testis.
Skills the Lab Values
RNA sequencingCRISPR/Cas9mass spectrometryimmunoprecipitationknockout mouse modelschromatin immunoprecipitation (ChIP-seq)Western blottingcell culturegene expression analysis
Output against the department
Publications103bottom 36% of dept.661st of 1,033
this lab
most publishedleast published
Citations2.3kbottom 16% of dept.867th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.