Tufts University · BiochemistryWhite Lab
Elizabeth A White · Medford, Massachusetts
Research Focus
Dr. Elizabeth A White's lab at Tufts University focuses on understanding how high-risk human papillomavirus (HPV) manipulates host cell signaling to promote persistent infections and contribute to cancer development. By studying the viral proteins E6 and E7, the lab explores their roles in cellular transformation, including how they disrupt signaling pathways that normally regulate cell growth and differentiation. This research aims to uncover mechanisms that could lead to new therapeutic strategies for HPV-related cancers.
human papillomaviruscell signalingcarcinogenesistumor suppressor proteinshost cell reprogramming
Research Aims
5AIM 01Investigate how HPV E7 degradation of PTPN14 activates YAP1 signaling.
AIM 02Determine the role of RB1 and PTPN14 in HPV-induced host cell reprogramming.
AIM 03Elucidate the mechanisms through which HPV E7 contributes to cellular transformation.
AIM 04Assess how alterations in cell signaling pathways drive HPV-related cancers.
AIM 05Explore potential therapeutic interventions targeting HPV E7 signaling pathways.
Skills the Lab Values
cell culturemolecular cloningWestern blotRNA sequencingattenuated virus assaysimmunoprecipitation3D cell culture modelsconfocal microscopyprotein-protein interaction studies
Output against the department
Publications155bottom 44% of dept.224th of 402
this lab
most publishedleast published
Citations3.4kbottom 16% of dept.337th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.