University of California-Davis · PhysiologySantana Lab
Luis F Santana · Davis, California
Research Focus
Dr. Luis F. Santana's lab focuses on understanding how the heart’s natural pacemakers function and are influenced by their blood supply and metabolic activity. They explore how the cells in the sino-atrial node generate electrical signals to control heartbeats, especially during heart failure. The lab combines experimental techniques and computer models to uncover the complexities of cardiac excitability and rhythm regulation, aiming to develop new treatment strategies for heart rhythm disorders.
cardiac pacemakingsino-atrial nodeheart failuremetabolic controlelectrophysiologyATP dynamicsvascular supplystochastic resonancemyocyte excitability
Research Aims
3AIM 01Investigate how stochastic resonance enhances the rhythmic activity of sino-atrial node myocytes.
AIM 02Examine the fluctuation of ATP consumption in sino-atrial node myocytes during heartbeats.
AIM 03Assess the impact of regional blood supply on myocyte excitability and pacemaking during heart failure.
Skills the Lab Values
electrophysiological recordingcellular imagingmathematical modelingdata analysisvascular imagingtissue culturestatistical analysisbiochemical assayscomputer simulations
Output against the department
Publications226top 27% of dept.77th of 286
this lab
most publishedleast published
Citations12ktop 26% of dept.73rd of 286
this lab
most citedleast cited
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