Washington University in St Louis · GeneticsProvince Longevity Lab
Michael A. Province · Saint Louis, Missouri
Research Focus
Dr. Michael A. Province's lab studies families with exceptional longevity to understand the genetic and biological factors that promote healthy aging. The research focuses on analyzing data collected from over 4,900 participants in the Long Life Family Study, exploring how genes influence various aspects of health in old age. The goal is to identify protective genetic variants and mechanisms that may help in developing new therapies and prevention strategies against age-related illnesses, like Alzheimer's disease.
longevityhealthy aginggenetic variantsAlzheimer's diseasefamily studylongitudinal analysisomicsmachine learningdiversitybig data
Research Aims
5AIM 01Identify genetic variants associated with exceptional longevity.
AIM 02Analyze the impact of ancestry on healthy aging traits.
AIM 03Investigate the biological mechanisms behind cognitive resilience.
AIM 04Expand the diversity of study participants to enhance findings.
AIM 05Utilize advanced AI techniques to model gene interactions in aging.
Skills the Lab Values
genome sequencingbioinformaticsdata analysislongitudinal study designtranscriptomicsmetabolomicsclinical assessmentsystems biologyartificial intelligenceepigenetics
Output against the department
Publications522top 12% of dept.30th of 259
this lab
most publishedleast published
Citations42ktop 15% of dept.38th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.