Tulane University of Louisiana · BiologyAR Insight Lab
Yan Dong · New Orleans, Louisiana
Research Focus
Dr. Yan Dong's lab at Tulane University focuses on understanding how prostate cancer develops resistance to hormone therapies by studying the role of RNA-binding proteins, particularly the androgen receptor (AR). The lab explores innovative approaches to target AR's RNA interactions, which could lead to new treatment strategies for prostate cancer patients. By shedding light on the mechanisms that contribute to cancer progression, this research aims to improve therapeutic outcomes for those affected by prostate cancer.
androgen receptorprostate cancertherapeutic resistanceRNA-bindingsplicing factors
Research Aims
2AIM 01Elucidate the impact of AR-RNA interactions in prostate cancer progression and resistance to AR-targeting therapies.
AIM 02Determine the mechanisms by which AR regulates pre-mRNA splicing.
Skills the Lab Values
RNA splicing analysiscell culture techniquesmolecular cloningCRISPRgene expression analysisXenograft modelsbioinformaticsWestern blottingIn vitro assays
Output against the department
Publications182top 36% of dept.371st of 1,033
this lab
most publishedleast published
Citations5.6kbottom 41% of dept.611th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.