University of Rochester · NeuroscienceHIV and Neurocognition Lab
Steven Alan Goldman · Rochester, New York
Research Focus
Dr. Steven Alan Goldman's lab at the University of Rochester focuses on understanding how HIV affects the human brain, particularly how it leads to cognitive disorders. They employ unique mouse models that incorporate human brain cells to better study the effects of this virus, especially in conjunction with factors like drug addiction. The lab aims to uncover how HIV alters brain cell functions and contributes to cognitive problems in infected individuals.
HIVneurocognitive disordersastrocytesmicrogliachimeric modelsdrug addictiongene expressionmethamphetamineCNS
Research Aims
5AIM 01Develop a chimeric mouse model with human astrocytes and microglia to study HIV effects on the brain.
AIM 02Investigate how HIV infection impacts dendritic architecture of neurons in the striatum.
AIM 03Assess the effects of chronic methamphetamine use on human astrocytes and their interaction with HIV.
AIM 04Identify transcriptional changes in glial cells in response to HIV infection and methamphetamine exposure.
AIM 05Evaluate behavioral outcomes in HIV-infected chimeric mice to understand cognitive deficits.
Skills the Lab Values
animal modelscell culturesingle cell RNA sequencinggene expression analysisimmunohistochemistrymicroscopybehavioral assaysviral tracing techniques
Output against the department
Publications336top 20% of dept.133rd of 671
this lab
most publishedleast published
Citations41ktop 8% of dept.56th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.