University of Missouri-St Louis · ChemistryWong Lab
Chung F. Wong · Saint Louis, Missouri
Research Focus
Dr. Chung F. Wong's lab at the University of Missouri-St. Louis focuses on computer-aided methods to design drugs that target protein kinases, which are crucial in treating cancers like lung cancer. The lab uses advanced simulations to improve the understanding of how drugs bind to these proteins, especially in patients with specific mutations. This innovative research aims to develop new therapies that are more effective against various cancers by leveraging computational tools and machine learning techniques.
computer-aided drug designprotein kinaseslung cancermolecular simulationsdrug binding kinetics
Research Aims
5AIM 01Improve drug-binding kinetics simulation methods for protein kinases.
AIM 02Perform systematic analysis to identify key interactions in kinase-ligand systems.
AIM 03Predict drug response for lung cancer mutations in EGFR mutants.
AIM 04Utilize machine learning to enhance drug binding predictions for protein mutants.
AIM 05Identify therapeutic compounds suitable for specific protein kinases in cancer treatment.
Skills the Lab Values
molecular dynamics simulationcomputer-aided drug designmachine learningmolecular dockingprotein modeling
Output against the department
Publications113bottom 24% of dept.164th of 216
this lab
most publishedleast published
Citations2.6kbottom 19% of dept.176th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.