University of Kentucky · PhysiologyMacauley-Rambach Lab
Shannon L Macauley-Rambach · Lexington, Kentucky
Research Focus
Dr. Shannon L Macauley-Rambach's lab at the University of Kentucky focuses on understanding the role of microglial metabolism in Alzheimer's disease. The research investigates how changes in the metabolic processes of brain cells, particularly microglia, impact the development and progression of Alzheimer's pathology. The lab explores whether targeting these metabolic shifts can help reduce the harmful effects of the disease and opens new avenues for potential therapies.
Alzheimer's Diseasemicroglial metabolismlactateneuroinflammationamyloid-betaglucose metabolismneurodegenerationmetabolic flux
Research Aims
5AIM 01Investigate how microglial metabolism influences Alzheimer's disease progression.
AIM 02Determine the role of lactate production in microglial function.
AIM 03Explore therapeutic targets for reducing Alzheimer's-related pathology.
AIM 04Assess the impact of metabolic changes on neuroinflammation.
AIM 05Evaluate the effects of glucose uptake alterations in the brain.
Skills the Lab Values
cell culturemouse modelsmetabolomicsneuroimaginggene expression assayspharmacological inhibitionWestern blotPCRmicrodialysis