Duke University · BiochemistryYokoyama Enzyme Lab
Kenichi Yokoyama · Durham, North Carolina
Research Focus
Dr. Kenichi Yokoyama's lab at Duke University focuses on understanding how enzymes that utilize metals (metalloenzymes) work, particularly in the creation of essential compounds found in nature. They study the way these enzymes help synthesize complex molecules and investigate how to block the action of key fungal enzymes to combat fungal infections. Overall, their research aims to reveal new ways to develop drugs that can help treat significant health issues caused by pathogenic fungi.
metalloenzymesnatural product biosynthesischitin synthesisantifungal antibiotic developmentenzyme catalysis
Research Aims
3AIM 01Elucidate the mechanisms of metalloenzymes in cofactor and natural product synthesis.
AIM 02Investigate the catalysis and inhibition of chitin synthases in pathogenic fungi.
AIM 03Develop a comprehensive understanding of the molecular basis for antifungal drug efficacy and resistance.
Skills the Lab Values
X-ray crystallographycryoelectron microscopyenzyme kineticsprotein purificationchemical synthesisbioinformaticsmolecular modeling
Output against the department
Publications164bottom 47% of dept.214th of 402
this lab
most publishedleast published
Citations3.1kbottom 14% of dept.344th of 402
this lab
most citedleast cited
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