Michigan State University · BiochemistryThe Genomic Immunity Lab
Jennifer B Jacob · East Lansing, Michigan
Research Focus
Dr. Jennifer B Jacob's lab focuses on discovering and targeting genes involved in cancer progression, specifically using mouse models that mimic human cancers. They investigate regulatory genes and their potential as targets for cancer therapies, studying immune responses and intervention strategies to improve treatment outcomes. Through advanced genetic analysis and bioinformatics, the lab aims to enhance our understanding of tumor immunity and develop new cancer treatment approaches.
cancer researchtumor immunityGENE therapymouse modelsfunctional genomicsimmunotherapycancer biomarkersHER2/NeuQTL analysis
Research Aims
3AIM 01Identify candidate genes that regulate cancer progression
AIM 02Define expression profiles of candidate genes and select actionable targets
AIM 03Test the role of LILRB4 in tumor immunity to impede tumor growth
Skills the Lab Values
PCRmouse modelsRNA sequencingbioinformaticsflow cytometrygenetic knockout techniquesimmunological assaysWestern blottingsingle-cell RNA sequencing,data analysis in R
Output against the department
Publications48bottom 7% of dept.373rd of 402
this lab
most publishedleast published
Citations725bottom 1% of dept.397th of 402
this lab
most citedleast cited
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