EUEmory University · Biology
HIV Reservoir Dynamics Lab
Una T O'Doherty · Atlanta, Georgia
Research Focus
Dr. Una T. O'Doherty's lab at Emory University focuses on understanding HIV, particularly why HIV reservoirs behave differently in various patients. The lab studies the role of different types of T cells, especially naive CD4+ T cells, which were previously thought to be less significant in HIV persistence. The team uses advanced techniques like machine learning and sequencing to reveal insights that could lead to new ways of reducing the size of the HIV reservoir and improving treatment strategies.
HIVnaive T cellsHIV reservoirsmachine learningsequencingantiviral therapyimmune responseviral persistencelatency
Research Aims
3AIM 01Determine the contribution of infected naive T cells to HIV reservoir dynamics.
AIM 02Develop an ex vivo model to study naive T cell contributions to the HIV reservoir.
AIM 03Use mathematical models to dissect the role of naive and memory T cells in HIV persistence.
Skills the Lab Values
PCRcell culturenext generation sequencingbioinformaticsmathematical modelingflow cytometryclonal trackingRNA sequencingCRISPR/Cas technology
Output against the department
Publications74bottom 21% of dept.813th of 1,033
this lab
most publishedleast published
Citations6.3kbottom 45% of dept.567th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.