University of Florida · PharmacologyThe Hormone and Neurohealth Lab
Gemma Casadesus · Gainesville, Florida
Research Focus
Dr. Gemma Casadesus's lab focuses on understanding how hormonal changes during menopause affect brain health, particularly in relation to Alzheimer's disease (AD). The lab investigates the role of the LH/CG receptor, which is linked to neuroinflammation and cognitive decline. By exploring how this receptor can influence immune responses in the brain, the research aims to uncover potential therapeutic strategies for women at risk of developing AD as they age.
Alzheimer's DiseaseMenopauseNeuroinflammationHormone RegulationImmune Modulation
Research Aims
3AIM 01Evaluate the role of the LH/CG receptor in neuroplasticity and inflammation in the brain.
AIM 02Assess how hormone receptor activation can mitigate inflammation linked to Alzheimer's disease.
AIM 03Investigate how age and reproductive status affect the expression and therapeutic potential of hormone receptors in the brain.
Skills the Lab Values
animal modelsCell cultureimmunohistochemistryWestern blotPCRflow cytometryRNA sequencing
Output against the department
Publications220top 38% of dept.174th of 462
this lab
most publishedleast published
Citations14ktop 28% of dept.128th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.