The University of Texas Medical Branch at Galveston · NeuroscienceThe Tau Resilience Lab
Giulio Taglialatela · Galveston, Texas
Research Focus
Dr. Giulio Taglialatela's research lab focuses on understanding the early molecular events that cause Alzheimer's Disease (AD), specifically how different forms of toxic tau protein impact synapses in the brain. The lab investigates why some individuals can remain cognitively healthy despite having signs of AD pathology, aiming to develop new therapies that protect synapses from tau-induced damage. Through this work, the lab seeks to uncover the mechanisms behind synaptic resilience and vulnerability in neurological diseases.
Alzheimer's Diseasetau oligomerssynaptic functionresilience in ADneuropathology
Research Aims
3AIM 01Investigate the binding dynamics of tau oligomer conformers to synaptic receptors.
AIM 02Evaluate the functional impact of tau oligomers on human synapses across different tauopathies.
AIM 03Document mechanisms of synaptic interaction and resistance related to tau in Alzheimer’s disease.
Skills the Lab Values
cell cultureWestern blotfluorescence microscopyprotein purificationmolecular biology techniques
Output against the department
Publications200top 37% of dept.248th of 671
this lab
most publishedleast published
Citations7.1kbottom 48% of dept.347th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.