University of Rochester · Microbiology & ImmunologyThe Atherosclerosis Dynamics Lab
Juilee Thakar · Rochester, New York
Research Focus
Dr. Juilee Thakar's lab at the University of Rochester focuses on understanding how HIV infection influences cardiovascular diseases, particularly atherosclerosis. They study the role of platelet-monocyte interactions and how these contribute to chronic inflammation and the acceleration of atherosclerosis in HIV-infected individuals. By using advanced techniques like single-cell sequencing and molecular modeling, their research aims to uncover mechanisms behind these processes and identify potential biomarkers for early detection and new therapeutic targets.
HIVatherosclerosisplatelet-monocyte interactionsmicro-RNAchronic inflammation
Research Aims
4AIM 01Define and model molecular networks in monocytes interacting with activated platelets in HIV+ patients.
AIM 02Characterize micro-RNA and proteins from platelet-derived microparticles in HIV+ individuals.
AIM 03Investigate the signaling pathways affected by miRNA and protein transfer in monocyte differentiation.
AIM 04Test the binding of differentiated monocytes to human carotid endothelial cells.
Skills the Lab Values
CITE-seqsmall-RNA sequencingproteomicsmolecular modelingmachine learning
Output against the department
Publications125bottom 47% of dept.255th of 486
this lab
most publishedleast published
Citations2.5kbottom 15% of dept.413th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.