University of Missouri-Columbia · PharmacologyMartinez-Lemus Lab
Luis A Martinez-Lemus · Columbia, Missouri
Research Focus
Dr. Luis A Martinez-Lemus leads a research lab focused on understanding how obesity contributes to cardiovascular disease, particularly through arterial stiffening and hypertension. The lab investigates the role of tissue transglutaminase, an enzyme that may be targeted to develop new therapies to improve vascular health and reduce heart disease risks in obese patients. By exploring the underlying mechanisms and testing pharmacological interventions, the lab aims to find innovative approaches to treat these conditions.
arterial stiffeninghypertensionobesityvascular remodelingtissue transglutaminase
Research Aims
3AIM 01Determine the mechanism of SMC mineralocorticoid-dependent regulation of TG2 in obesity.
AIM 02Explore the role of TG2 mechanosensation in arterial stiffening and remodeling in obesity.
AIM 03Test the de-stiffening effects of TG2 inhibition in isolated arteries from obese patients.
Skills the Lab Values
cell cultureanimal modelsgenetic manipulationpharmacological experimentsWestern blotPCRmicroscopy
Output against the department
Publications220top 38% of dept.175th of 462
this lab
most publishedleast published
Citations5.4kbottom 40% of dept.277th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.