Thomas Jefferson University · BiochemistryOral Cancer Research Unit
Christine M. Eischen · Philadelphia, Pennsylvania
Research Focus
Dr. Christine M. Eischen's lab at Thomas Jefferson University focuses on studying oral squamous cell carcinoma (OSCC), a common and aggressive oral cancer. The research aims to uncover new vulnerabilities in OSCC, especially in cases where the tumor suppressor p53 is inactivated, to improve treatment methods. The lab is investigating a novel protein degrader that targets Mdm2, a protein essential for the survival of p53-null cancers, with the goal of increasing tumor immunogenicity and overcoming resistance to current therapies.
oral squamous cell carcinomap53Mdm2immunotherapycancer biologyprotein degradationtumor suppressorHPV-negative cancer
Research Aims
5AIM 01Investigate the role of Mdm2 in p53-inactivated OSCC cells.
AIM 02Assess the cytotoxic effects of novel Mdm2-targeted therapeutics.
AIM 03Explore the immunogenicity of OSCC tumors in response to targeted therapies.
AIM 04Study the pathways involved in apoptosis signaling in OSCC.
AIM 05Develop and test new treatment strategies to enhance efficacy against OSCC.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingmicroscopyprotein degradation techniquesdrug designtumor immunologycytotoxicity assays
Output against the department
Publications245top 31% of dept.122nd of 402
this lab
most publishedleast published
Citations9.0kbottom 46% of dept.216th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.